Clarksdale, in the Mississippi Delta, it a major stop on the Mississippi Blues Trail. From the 1920s through the 1950s, the culture of music and the blues blossomed in Clarksdale, with a radio station devoted to it and many great artists, including Charlie Patton, Bukka White, and Ike Turner, who called the city home. Today, visitors to Clarkson can check out the Delta Blues Museum for a look at this colorful history, and if they time their visit right, even stay for the Sunflower River Blues Festival. But no matter the time of year, there's sure to be some great live music in Clarksdale's blues bars, such as the Ground Zero Blues Club.

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