Mount Gleason is the fifth-most-prominent mountain peak within the San Gabriel Mountains, included on the Sierra Club's Hundred Peaks List for its international renown. The mountain is located along the western end of the mountain range and is covered in conifer tree ecosystems, accessible via vehicle from Mount Gleason Road. A wide range of hiking trails are also offered to reach the summit of the mountain, including the Pacific Crest Trail, which runs the length of the mountain's spine and is accessible to hikers via Mill Creek Summit, a hike that spans 16 miles in total. Campgrounds that are available for overnight stay for summit hikers include the Lightning Point and Messenger Flats Campgrounds, both located on the mountain itself. Vehicular visitors should note that Mount Gleason Road is a very steep upward drive and is recommended for drivers of high skill level.

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