Tumacacori National Historical Park is a 360-acre park located in the upper Santa Cruz River Valley in southern Arizona. The park was created to protect the ruins of three Spanish missions, two of which are National Historic Landmarks. Tumacácori is located in the Santa Cruz River valley, a cultural crossroads where O’odham, Yaqui, and Apache people lived and met with European Jesuit and Franciscan missionaries, white settlers, and soldiers, at times in conflict and times in cooperation. The park also contains the 1937 Tumacácori Museum, also a National Historic Landmark. Tumacácori National Historical Park tells the stories of the influence Spanish missions had on the American Indian communities of the area of Pimería Álta and on the culture of the American southwest.

Off exit 29 on I-19, Arizona