San Luis Obispo is centrally located in California between Los Angeles and San Francisco and is known as one of the “happiest places in America.” The small town is seated between the Pacific Ocean and inland mountains and offers thousands of acres of protected outdoor space, a stellar wine growing region, and a walkable and vibrant downtown. San Luis Obispo is home to California Polytechnic State University, known as Cal Poly, it’s one of the top-ranked universities in America. Visit the 1792 Mission San Luis Obispo Tolosa. The mission was the fifth in California founded by Father Junipero Serra and has been beautifully restored. Downtown’s shopping and dining district is across the mission plaza.