The legendary Florida Keys lie off the southern-most point of Florida, approximately two and a half hours from Fort Lauderdale. Although it is possible to drive the all the way from Miami to Key West and back on a day trip, you will not have any time to stop and explore. A better idea would be to consider spending a night somewhere along the way. The over-ocean drive from Key Largo to Key West, along U.S. 1 is considered to be one of the world’s most scenic drives. The delightful islands which make up The Florida Keys each have something special to add to your adventure including sensational snorkeling and scuba diving, sports fishing, and a laid-back tropical island atmosphere.