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Founded in 1702, Mobile is the oldest city in Alabama and one of the oldest in the US. Everywhere you turn you are surrounded by history; a good place to start your tour of the city would be the History Museum of Mobile, which will give you a great introduction to the other historic attractions.
You can explore the famous African American Heritage Trail (which includes no less than 40 historic sites), get a glimpse of even earlier times at the University of South Alabama Archaeology Museum, stroll through historic downtown Mobile, or tour the Phoenix Fire Museum and the Mobile Medical Museum. For a break from history you can spend a few fascinating hours at the Gulf Coast Exploreum Science Center.
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