How Far is San Diego from San Francisco: Driving, By Plane, Train or Bus

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San Francisco, the largest city in Northern California, is some 500 miles away from the state’s southernmost city, San Diego. The area between the two cities is where the most of California’s population resides. On the way from one city to the other, you have to go past several large settlements, most notably, the second-largest city in the United States, Los Angeles.