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Review:
If you choose to drive to Napa from San Francisco for your day trip, the route you take will depend on your starting point. Those on the West Side of the Bay, for example, will want to go over the Golden Gate Bridge and then follow US-101 and CA-37 north and following the signs for Napa. If you're over on the East Side, however, you'll be better off following the I-80 and eventually connecting with the CA-29.
Either way, the drive will take about an hour in total, and then once you get to Napa, you'll have the freedom to either park up and check out the city or carry on to local wineries and vineyards. The advantage of driving to Napa for your day trip is that a car allows you to choose when you set off, when you head back, where you park, and where you stop along the way.
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