Galena is Illinois' second most-popular tourist destination after Chicago, best known as the hometown of Civil War general and United States President Ulysses S. Grant, whose Italianate-style home in the city has been converted into a living history museum. The city is home to a large number of preserved Victorian-era homes and businesses, many of which are preserved within the National Register of Historic Places-listed Galena Historic District. It has been named as one of America's prettiest towns by Forbes and has been acclaimed by Travel and Leisure for its historic all-American Main Street, which is home to a wide variety of quaint shopping, dining, and nightlife options. On the town's outskirts, Horseshoe Mound preserves an indigenous ceremonial mound and offers views of three neighboring states.

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